Hyperhidrosis

We are committed to helping millions of patients who suffer from hyperhidrosis.

Hyperhidrosis is a skin condition in which excessive sweating occurs beyond what is physiologically required to maintain normal thermal regulation. Sweat is produced by glands in the skin and released to the skin surface through ducts. Sweat gland activity is controlled by the nervous system. The nervous system transmits signals to the sweat glands through the neurotransmitter acetylcholine.

Primary hyperhidrosis, which is excessive sweating without a known cause, can affect the underarms (axillary hyperhidrosis), palms of the hands, soles of the feet, face and other areas.

A condition that affects nearly 5 percent of the U.S. population.

Hyperhidrosis affects an estimated 4.8 percent of the U.S. population, or roughly 15.3 million individuals.1 Of these, 65 percent, or nearly 10 million people, suffer from sweating localized to the underarms (axillary disease). Hyperhidrosis typically starts at age 10 to 12 and occurs through ages 40 to 60. The condition impacts men and women equally.

More than half of patients with primary axillary hyperhidrosis, or 5.2 million Americans, have severe disease that is barely tolerable and frequently interferes with daily activities, or that is intolerable and always interferes with daily activities.1 Several studies have demonstrated that excessive sweating often impedes normal daily activities and can result in occupational, emotional, psychological, social and physical impairment. Patients suffering from hyperhidrosis often report a feeling of helplessness that can negatively affect their mental well-being and overall quality of life.

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Few treatment options are available.

Hyperhidrosis has historically been undertreated, and few treatment options are available. The most common treatments include:

  • Topical antiperspirants
  • Injectable treatments
  • Surgical procedures

As a result, new treatment options are needed that can help address the needs of patients in this therapeutic area.

  • 1 Doolittle J, Walker P, Mills T, Thurston J. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res. 2016;308:743-749.